Testosterone undecanoate softgel

Chemical Name: Molecular Weight: 288.42 g/mol Formula: C H O Testosterone undecanoate was introduced in China for use by injection and in Europe for use by mouth in the 1970s. It became available for use by injection in Europe in the early to mid 2000s and in the United States in 2014. A formulation for use by mouth is not currently available in the United States but is pending approval as of 2018. Along with testosterone enanthate, testosterone cypionate, and testosterone propionate, testosterone undecanoate is one of the most widely used testosterone esters. However, it has advantages over other testosterone esters in that it can be taken by mouth and in that it has a far longer duration when given by injection. In addition to its medical use, testosterone undecanoate is used to improve physique and performance. The drug is a controlled substance in many countries and so non-medical use is generally illicit Pharmacodynamics See also: Testosterone & Mechanism of action, and Anabolic steroid Pharmacology Testosterone undecanoate is a prodrug of testosterone and is an androgen and anabolic-androgenic steroid (AAS). That is, it is an agonist of the androgen receptor (AR). Pharmacokinetics Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection. Its elimination half-life is 20.9 days and its mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil. These values are substantially longer than those of testosterone enanthate (which, in castor oil, has values of 4.5 days and 8.5 days, respectively). Testosterone undecanoate is administered via intramuscular injection once every three months or so. 30 48 3 Testosterone undecanoate softgel Each softgel .............................................................................40 mg testosterone undecanate DOSAGE: Testosterone undecanoate is used in androgen replacement therapy. It is specifically approved only for the treatment of hypogonadism. As an intramuscular injection, it is administered at a dosage of 1,000 mg once every 12 weeks. Conversely, oral testosterone undecanoate must be taken two or three times a day with food SIDE EFFECTS: Side effects are similar to other testosterones but it should be noted that the effects diminish quickly after use and because of its water based solution, the injection sited stays tender for a long time. CONTRAINDICATIONS: Testosterone undecanoate are contraindicated in men with carcinomas of the breast or with known or suspected carcinomas of the prostate and in women who are or may become pregnant. PRECAUTIONS: Peliosis hepatis can be fatal complication, Testosterone undecanoate should be discontinued, if cholestatic hepatitis with jaundice appears. Geriatric patients may be a the risk for the development of prostatic hypertrophy and prostatic carcinoma. Caution is required in patients with pre existing cardiac, renal or hepatic disease, due to sodium and water retention properties of androgens DRUG INTERACTIONS: When administered concurrently, the following drugs may interact with androgens: Oral anticoagulants, Antidiabetic drugs and insulin, ACTH & corticosteroids, oxyphenbutazone. STORAGE: Testosterone undecanoate should be stored at room temperature. www.norexpharma.com Rue Jean Jaures 12 Charlerroi, WHT 6001 Belgium 40 mg x 30 softgels